The health-related quality of life (HRQL) contains many aspects under patients' health as physical, psychological, social function and a general prosperity. Numerous clinical studies have established the importance of quality of life in various diseases. It is extremely popular to assess the quality of life in clinical trials as a measure of the subjective state of health of patients. The HRQL, also gradually recognized as an important measure of outcome after organ transplantation. Along with other indicators related to the improvement of patient and graft survival, quality of life has been assessed as a valid outcome measure. Investigations on the quality of life are aimed to lead to a broader view of subjective health, consider that health is a puzzle of the general welfare. Kidney transplantation is the treatment of choice in end stage renal failure. Progress in renal transplantation and immunosuppressive therapies have increased significantly in recent decades, resulting in allograft survival rates at one year is now over 90%. The main goal of transplantation is to achieve maximum quality and longevity while minimizing the impact of disease and health care costs. In general, the quality of life improved after successful renal transplantation compared with patients on dialysis, and the result was more pronounced in men than in women. In these studies it seems clear that renal transplantation is not only cheaper replacement therapy over time, but also linked to lower mortality and better quality of life for patients.