Introduction: Local anesthetics are most drug often used in dentistry, notably safe drug being considered when administered carefully and within limits therapeutic dosages. Demand to demonstrate possible cardiovascular changes of clinical significance relating to the use of local anesthetics associated to vasoconstrictors are extensive and aims to make sure about the safety of its clinical use. The aim of this

study was to evaluate the cardiovascular effects resulting from infiltrative administration 3% mepivacaine hydrochloride (54mg) and 2% mepivacaine hydrochloride (36mg) associated with epinephrine hydrochloride 1: 100,000 (18mg).

 

Method: Twenty normotensive patients’ volunteers were evaluated during low complexity restorative procedure in upper posterior teeth. During the experiment were monitored the blood pressure and heart rate through the oscillometric and fotopletismográfico method for non-invasive monitor. Mean values were recorded every minute and continuously during the Es of the experiment as follows: Phase 1 - control

period (10 min.). On Phases 2 and 3 the Es were: (E1) baseline period (10 min.), (E2) preparation period (3 min.), (E3) anesthesia period (2 min.), (E4) anesthesia latency period (5 min ) (E5) restorative period (10 min), (E6) final period (10 min).

 

Results: The changes observed in the cardiovascular parameters by the statistical analysis did not represent clinical manifestations or even patients’ reports at any time during and after the experiment.

Conclusion: According to the results mepivacaine with or without vasoconstrictor did not induce significant changes in cardiovascular dynamics.