Effect of Submucosal Platelet Rich Plasma Injection on the Rate of Orthodontic Tooth Movement: A Randomized Split Mouth Trial
Safa B. Alawy, Safaa M. Gaballah, Mohammed M. Ellaithy
Background: Platelet Rich Plasma (PRP) is one of the recent modalities introduced to accelerate
orthodontic tooth movement (OTM). The aim of this split-mouth trial was to investigate the effect of PRP
injection on the rate of OTM.
Methods: Fourteen patients requiring bilateral first premolar extraction and upper canine retraction
with maximum anchorage were included. A split mouth design was adopted in the study. Submucosal
PRP injection (70 units) was randomly assigned to one side of the maxillary arch (experimental side),
while the other side served as control. PRP injected disto-buccal and disto-palatal to the maxillary
canine. Digital models were used to evaluate the monthly rate of canine retraction and anchorage loss.
Results: Three patients dropped out, and eleven were analyzed. The mean rate of canine retraction was
significantly higher in the experimental side compared to control side in the first month (P ≤ 0.05), with
no significant differences in the remaining months.
Conclusions: Submucosal PRP injection can be effective and safe method for acceleration of orthodontic tooth movement on short term.
