Atopic dermatitis is a chronic relapsable inflammatory skin disease, and strongly associated with skin barrier dysfunction and susceptibility to infections. Atopic cheilitis is common in cases of atopic dermatitis. Topical tacrolimus is first-line treatment for the atopic dermatitis but it may cause many side effects after a long-time management. Now we describe a case of Staphylococcus haemolyticus infection in a patient with atopic cheilitis. Clinicians should be aware of this rare complication particularly in the special area of skin