Effectiveness of Subgingivally Delivered 0.4% Moxifloxacin Gel and 0.1% Oflaxacin Gel in the Treatment of Chronic Periodontitis
Kranti K, Mani R, Ashutosh R. Tervankar
Background: Local delivery of antimicrobials in sustained or controlled delivery systems are used to enhance the effect of non-surgical periodontal therapy.
Aim: Aim of the present study was to investigate and compare the effectiveness of subgingivally delivered antimicrobial bio-absorbable controlled release 0.4% Moxifloxacin gel and 0.1% Ofloxacin gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis.
Methods and material: A total of 62 patients suffering from chronic periodontitis were randomly divided into group A and group B. The group A were treated with Scaling & Root Planing (SRP) in combination with subgingival application of 0.4% Moxifloxacin gel. The group B received SRP and subgingival application of 0.1% Ofloxacin gel. Probing Depth (PD) and Clinical Attachment Level (CAL) were recorded at baseline, 3, 6 and 9 months.
Statistical analysis: Statistical analysis was done using oone way Analysis of Variance (Anova) to test the difference between groups.
Results: The PD scores in experimental group A were 5.22, 3.71 and 3.71 mm and for the experimental group B were 5.30, 3.96 and 3.96 mm at baseline, 3 months, 6 months and 9 months respectively.
Conclusion: Overall, both the therapies led to significant improvements of the investigated parameters. Thus in periodontal pockets with PD of ≥ 5 mm, a single subgingival administration of a 0.4% Moxifloxacin gel and 0.1% of Ofloxacin gel as an adjunct to SRP may result in additional PD reduction compared to SRP alone