Strange Effect of a Synthesized Nanopackage Towards A549, Huh-7, A-375, KB44,
MCF-7 And HT29 Human Cancer Therapy
Zahra Fakhroueian¹, Pouriya Esmaeilzadeh², Seyed-Behnam Ghaffari³, Pegah Esmaeilzadehâ´
In this research, an unrivaled water-based eco-friendly nanopackage was designed including ZnO@modified-CNTs, alumina@silica, ZnO quantum dot NPs, pharmaceutical binder, viscosity control, emulsifier and dispersing agents. Characterizing the final nanofluid, the SEM,
FTIR, XRD and UV-Vis were applied. The inhibition of cell growth for this nanopackage was evaluated by MTT assay against A549, Huh-7,
A-375, KB44, MCF-7, and HT29 cell lines after incubation period of 24 and 48 h. Interestingly, the nanopackage treatments during 48 h
showed no toxicity against normal human foreskin fibroblast cells (HFF-2) as a control. The obtained values of IC50 (μg/ml) were determined
as follow: A549 cells (60), Huh-7 cells (75), A-375 cells (90), KB44 cells (65), MCF-7 cells (50), and HT29 cells (75) after 48 h of exposure with
comparison of 195 (μg/ml) for control, respectively (P<0.05). The nanoproduct indicated very potential as selective and smart cytotoxic
agent for inhibiting the growth, proliferation and eradication of these current cancer cells. Strong diffusion, smart surface modification,
structural defects and ROS process can possess extravagant roles in oxidation-reduction chemical reactions related to cancer therapy and
kinds of virus infections.
