T _reg and T _mem in Immunotherapy Platform: A Twilight of Life-long Immunity Against Cancer and Infection for Future Decade

 

Sharif M. Shaheen*

T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and tumor-infiltrating Tregs are often associated with a poor clinical outcome. Memory T-cells are derived from a normal T-cells that have learned how to overcome an invader by ‘remembering’ the strategy used to defeat previous infections. Here the impact of Tregs in the tumor microenvironment and its effect on CD8+T Cell as well as in antitumor activity was amplified so that a future antigen specific T-Cell stimulation (Protein/ DNA vaccine) can be patented. Moreover, recent innovation of central memory T-Cell have been considered to evaluate its role in future, having a lifelong immunity from Protein/DNA vaccine.