A Comprehensive Review of Surgical Supplies

Abdul Kader Mohiuddin
 

Injury to the skin provides a unique challenge, as wound healing is a complex and intricate process. Acute wounds have the potential to move from the acute wound to chronic wounds, requiring the physician to have a thorough understanding of outside interventions to bring these wounds back into the healing cascade. Surgical enrichment/dressings are applications for wounds, burns, and ulcers. They should be regarded as supportive of healing; are desirable but not essential in an emergency. There are currently plenty of dressings available in the market to aid in wound healing. Before choosing a dressing for a specific injury, a physician must assess carefully the needs of the wound to understand which dressing would ensure maximum interest. Basically, there is nothing called best choice, and it is crucial that the merits/demerits of each dressing system be understood. This article has provided a framework to assist in dressing assessment. This article reveals measurement of wound healing and the functions of wound dressings. A variety of dressings and their respective details are detailed.

In vivo antihyperlipidemic activity and preliminary phytochemical screening of bauhinia acuminate

Anusha Govindula* Musku Sadhana Reddy, Medi Manjula, Musku Soumya Reddy, Nusrath, Perumalla Kalyani

The recent prevalence of CVD has showed downward trend in many high-income countries, the global burden of CVD is still rising due to its increasing prevalence in lower- and middle-income countries where 80% of all global CVD-related deaths occur. Common significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia. The prevalence of dyslipidemia is very high in India, which calls for urgent lifestyle intervention strategies to prevent and manage this important cardiovascular risk factor. The present study was aimed to investigate the potential anti hyperlipidemic activity of Ethanolic leaf extract of Bauhinia acuminata in atherogenic diet induced rats. Preliminary phytochemical screening showed the presence of Flavanoids, alkaloids, steroids, Terpenoids. Acute toxicity study was performed on the rats using OECD Guideline no.423 and the maximum safe dose was found to be 5000mg/kg. Animals were grouped into Normal Control (Group-I), Disease Control (Group-II), Standard Group (Group-III) received Standard drug Atorvastatin 10mg/kg, and Test Group (Group-IV) received ethanolic extract of the plant with doses 200mg/kg and 400 mg/kg. The study was conducted for 30 days and Hyperlipidemia induced using Atherogenic diet. Statistical analysis was performed using Graph Pad Prism and the values are expressed as mean±SD values. Body weight changes were observed everyday upon Induction of Hyperlipidemia and it was drastically reduced in the rats with 400mg/kg dose (190±10) compared with the standard group (180 ±18.27). The present study showed that there is a significant reduction in the Total Cholesterol, VLDL, Triglycerides and increase in HDL level along with reduction in random blood Glucose level with ethanolic extract at a dose of 400mg/kg than 200mg/kg and the Standard Atorvastatin. Atherogenic Index of the plant extract 400mg/kg (1.62) 200mg/kg (4.69) also compared with Normal group (1.37), Disease Control Group (10) and Standard Group (3.11)

Method Development, Validation And Forced Degradation Studies Of Dolutegravir, An Anti-Retroviral Drug Using Uv-Visible Spectroscopy

K.Bhavyasri ^*, E.Divya

The aim of the present work is to develop sensitive, simple, accurate, precise and costeffective UV-spectrophotometric method for the determination of dolutegravir, an anti-retroviral drug, in bulk and pharmaceutical dosage form; and also to monitor the degrada-tion behavior of the drug under different stress conditions according to ICH guidelines.The method was developed by checking the solubility of the dolutegravir in various solvents.Dolutegravir is found to be freely soluble in the methanol. The method was developed using methanol and water. The absorbance maxima of dolutegravir using methanol was found to be at 259nm.The method showed high sensitivity of linearity range from 10-60μg/ml with a correlation coefficient (r²) of 0.9999 .The validation parameters were reported along with Limit of Detection (LOD) and Limit of Quantification (LOQ).The degradation behavior of the drug was studied by subjecting Dolutegravir to an acid and alkalinehydrolysis, oxidative, thermal and UV degradation. This study indicated that Dolutegravir was degraded in different stress conditions.