This research aim was to demonstrate the advantages of green methods of synthesizing biological active azaheterocycle-containing phosphonates in comparison with classical ones in the one-pot three-component Kabachnik-Fields reaction (boiling of mixture of cyclic amine, aromatic aldehyde and dimethylphosphite in benzene for 12-24 h). As it was expect microwave irradiation significantly reduced the

reaction time. In an ionic liquid (BMIB) 15 min of microwave irradiation is enough to form the target products. The effect of magnesium oxide on the reaction using 1-phenylpiperazine was noticeable. It shown the catalytic activity of oxides of magnesium and zinc on the preparing of aminophosphonates with an increase of microwave irradiation of reaction mixture up to 25 min. The lower yields of the products of benzhydryl derivatives, both under classical and microwave conditions could explained by a steric constraint created by the benzhydryl group.