Bones protect the different tissues of the body, produce different type of blood cells including immunity cells, store minerals, biomolecules, provide tensile strength for the shape, support, and to enable mobility [1,2]. Objectives: The objectives of the present study are to assess serum urea, uric acid, and creatinine of subjects with osteoporosis in Bundelkhand region and to know the association of the study parameters with osteoporosis in different age groups. Materials & Methods: Our study consisted of thirty six osteoporotic subjects and all subjects completed the physical and blood examinations performed from March to April 2019. A physical examination was performed on all subjects by a qualified doctor as per established standard methods. Exclusion criteria were severe osteoporotic individuals, more than five years of known duration and with other bone complications. Results: Majority of the patients were ≥ 56 years (54%).The mean age of patients was 57.6±9.52 years. Table 2 and Figure 2 show the distribution of subjects according to gender. Majority of subjects were females. Serum urea was not significantly altered in subjects aged <55 years when compared with >56 years. On the other hand serum uric acid and creatinine were significantly altered when compared between the subjects with age <55 years and subjects with age >56 years. Serum urea and creatinine were not significantly altered in male subjects when compared with female subjects of the subjects. On the other hand serum uric acid was significantly altered when compared between the male subjects with female subjects. Conclusion: We have demonstrated that higher serum uric acid and lower creatinine levels in osteoporosis subjects in the present study. With magnesium depletion existed within osteoporosis subjects therefore, it may be advisable to periodically monitor serum uric acid and creatinine concentrations in the same