A field experiment was carried out at Adet Agricultural research center to determine the effect of vermicompost in relation to the NP fertilizer on grain yield of wheat (Triticum aestivum) and chemical properties of soil at Adet experimental station in western Amhara, Ethiopia. The treatments include a combination of 0,3,6,9,and 12 ton vermicompost factorial combined with 0+0,46N+23P2O5 and 92N+46P2O5kg ha-1. The experiment was laid in a randomized complete block design with three replications. The higher (4125.6 kgha-1) grain yield and net benefit (62459.15 ETB ha-1) were obtained with the combination of 9ton vermicompost with 46N+23P2O5 kg /ha. The highest marginal rate of return (373.62%) with a net benefits of 48994.17 ETBha-1 was obtained from the combination of 3ton vermicompost with 92 N+46P2O5kg /ha. Soil chemical properties like soil pH, Total Nitrogen, Organic matter and availability of phosphorus improve from the initial.