How Does Heart Rate Control Improve the Treatment of Heart Failure?
João Lucas O’Connell*, Rodrigo Penha de Almeida, Gabriela Carolina Borges, Rose Mary Ferreira Lisboa da Silva, Anaisa Silva Roever-Borges, Elmiro Santos Resende, Nilson Penha-Silva, Leonardo Roever
Elevated heart rate is associated with poor cardiovascular outcomes. The reduction of heart rate is one of the goals in the treatment of patients with heart failure and reduced ejection fraction. The studies that involve the use of ivabradine, a drug which acts solely by decreasing heart rate, have shown that this effect, per se, reduces the risk of hospital admission and death in these patients. This review examines the results of studies that show reductions in the rate of myocardial oxygen consumption and shear stress, as well as increase in myocardial perfusion related to the reduction of heart rate.